INFLUENCE OF BASIC VARIABLES ON MICRONUCLEI FREQUENCY AND CHROMOSOMAL ABERRATIONS IN GENERAL POPULATION OF FB&H

  • Mirela Mačkić-Đurović University of Sarajevo, Faculty of Medicine, Bosnia and Herzegovina
  • Izeta Aganović-Mušinović University of Sarajevo, Faculty of Medicine, Bosnia and Herzegovina
  • Orhan Lepara University of Sarajevo, Faculty of Medicine, Bosnia and Herzegovina
  • Slavka Ibrulj University of Sarajevo, Faculty of Medicine, Bosnia and Herzegovina

Abstract

The aim of this study was to determine the values of micronuclei (MN) and structural chromosomal aberrations (CA) in peripheral blood lymphocytes from 200 healthy participants of both genders from general population of FB&H, as well as to explore the influence of gender and age on MN and CA frequencies. Standard protocols for MN test, cultivation and micronuclei analysis from peripheral blood binuclear lymphocytes have been applied. MN values ranged from 0 to 8 MN per 1000 binuclear cells. The results suggest that gender and age influence MN frequency, with pronounced effect on 2 MN frequencies. Females on average have higher values of all observed variables of MN test than men. We have also found significant effect of gender – females had increased number of CAs – chromatid type; and of the age in both genders. Frequency distribution of CTAs and CSAs between male and female groups showed predominance of CTAs over CSAs, independently of gender. The results of this study will be incorporated into reference data base for comparative research in future.

Published
2018-03-29
How to Cite
MAČKIĆ-ĐUROVIĆ, Mirela et al. INFLUENCE OF BASIC VARIABLES ON MICRONUCLEI FREQUENCY AND CHROMOSOMAL ABERRATIONS IN GENERAL POPULATION OF FB&H. Genetics & Applications, [S.l.], v. 1, n. 1, p. 44-50, mar. 2018. ISSN 2566-431X. Available at: <https://journal.genapp.ba/index.php/genapp/article/view/11>. Date accessed: 28 mar. 2024. doi: https://doi.org/10.31383/ga.vol1iss1pp44-50.
Section
Research Articles